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METABION TirzaFit Pen 60 mg / 3 ml
Metabion

METABION TirzaFit Pen 60 mg / 3 ml

TirzaFit disposable pre-filled pen 60 mg / 3 ml (Tirzepatide INN)

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❄️ Temperature-controlled delivery (2–8°C) across the EU.

GLP-1 / GIP Dual Agonist Once-Weekly Subcutaneous Pharmaceutical Grade

Overview

METABION TirzaFit 60 mg / 3 mL is a precision-engineered disposable injection pen loaded with high-purity Tirzepatide INN. Formulated with pharmaceutical buffers (disodium phosphate heptahydrate, sodium chloride, water for injections). Features a crystal-clear dosing window and smooth low-force injection mechanics.

Strictly for certified healthcare practitioners and clinical facilities

Dual Incretin Mechanism: GLP-1 + GIP Agonism

Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. By simultaneously activating both incretin pathways, it exerts synergistic metabolic control: promoting glucose-dependent insulin secretion from pancreatic beta cells, suppressing inappropriate glucagon release, slowing gastric motility, and stimulating central hypothalamic satiety circuits to curb appetite and enhance peripheral insulin sensitivity.

Dual Incretin Mechanism of Action (GLP-1 & GIP Synergy)
Dual Incretin Mechanism of Action • Synergistic GLP-1 & GIP receptor activation across brain, pancreas, stomach, and adipose tissue.

Administration

TirzaFit pre-filled 3 ml pen. Dial the dose number on the window, inject subcutaneously at 90°, and hold for 6 seconds to complete full delivery.

METABION TirzaFit Pen 60 mg / 3 ml
Pre-filled multi-dose disposable pen anatomy, dial mechanism, and 90° subcutaneous injection technique.

Clinical Dose Titration & Escalation Protocol

To ensure gastrointestinal tolerability, Tirzepatide administration must follow a stepwise escalation protocol. Treatment initiates at a low starting dose of 2.5 mg subcutaneously once weekly for the initial 4 weeks (adaptation phase). The dose is then increased to 5.0 mg once weekly. Subsequent increments of 2.5 mg may occur at minimum 4-week intervals based on clinical assessment and tolerance, up to the maximum dose of 15.0 mg weekly.

Clinical Titration and Escalation Schedule
Standard Once-Weekly Subcutaneous Escalation Schedule • Minimum 4-week adaptation periods between dose tiers.

Technical & Pharmaceutical Specifications

METABION TirzaFit Pen 60 mg / 3 ml Specifications
International Nonproprietary Name Tirzepatide INN
Strength & Volume 60 mg in 3 mL (20 mg/mL)
Excipients Disodium phosphate, NaCl, HCl, WFI
Delivery system 1 disposable pen with pre-filled cartridge
Brand / Distribution Metabion
Storage temperature 2°C to 8°C (Refrigerated)

Storage Requirements & Cold Chain Management

Store refrigerated at 2°C to 8°C (36°F to 46°F). Protect from direct light. Do not freeze. For pre-filled pens: once in use, the pen may be kept at room temperature (below 30°C / 86°F) for up to 21-28 days. For reconstituted vials: maintain in refrigerator at 2°C to 8°C and use sterile single-use syringes.

FAQ

What distinguishes the Metabion TirzaFit pen?

TirzaFit is buffered with an isotonic physiological matrix that minimizes injection-site discomfort and preserves peptide conformational stability.