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AFIRA Tirzepatide 60 mg (Lyophilized Powder)
Afira Biosystems

AFIRA Tirzepatide 60 mg (Lyophilized Powder)

Tirzepatide 60 mg lyophilized powder for solution for injection

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❄️ Temperature-controlled delivery (2–8°C) across the EU.

GLP-1 / GIP Dual Agonist Once-Weekly Subcutaneous Pharmaceutical Grade

Overview

AFIRA Tirzepatide 60 mg Lyophilized provides pharmaceutical-grade tirzepatide in a vacuum-sealed sterile glass vial. The lyophilized formulation preserves peptide structural integrity and maximizes shelf life. Requires reconstitution with sterile 0.9% sodium chloride or bacteriostatic water prior to subcutaneous administration.

Strictly for certified healthcare practitioners and clinical facilities

Dual Incretin Mechanism: GLP-1 + GIP Agonism

Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. By simultaneously activating both incretin pathways, it exerts synergistic metabolic control: promoting glucose-dependent insulin secretion from pancreatic beta cells, suppressing inappropriate glucagon release, slowing gastric motility, and stimulating central hypothalamic satiety circuits to curb appetite and enhance peripheral insulin sensitivity.

Dual Incretin Mechanism of Action (GLP-1 & GIP Synergy)
Dual Incretin Mechanism of Action • Synergistic GLP-1 & GIP receptor activation across brain, pancreas, stomach, and adipose tissue.

Administration

Reconstitution protocol: Slowly inject the diluent down the inner glass wall. Gently swirl the vial until the cake fully dissolves into a clear liquid. DO NOT SHAKE. Store the reconstituted solution in the refrigerator at 2°C to 8°C.

AFIRA Tirzepatide 60 mg (Lyophilized Powder)
Step-by-step sterile reconstitution protocol for lyophilized Tirzepatide with cold-chain maintenance (2°C - 8°C).

Clinical Dose Titration & Escalation Protocol

To ensure gastrointestinal tolerability, Tirzepatide administration must follow a stepwise escalation protocol. Treatment initiates at a low starting dose of 2.5 mg subcutaneously once weekly for the initial 4 weeks (adaptation phase). The dose is then increased to 5.0 mg once weekly. Subsequent increments of 2.5 mg may occur at minimum 4-week intervals based on clinical assessment and tolerance, up to the maximum dose of 15.0 mg weekly.

Clinical Titration and Escalation Schedule
Standard Once-Weekly Subcutaneous Escalation Schedule • Minimum 4-week adaptation periods between dose tiers.

Technical & Pharmaceutical Specifications

AFIRA Tirzepatide 60 mg (Lyophilized Powder) Specifications
Peptide purity (HPLC) > 99.2%
Vial content 60 mg Tirzepatide (Lyophilized Cake)
Dosage form Sterile lyophilized powder for solution
Recommended diluent Bacteriostatic Water or 0.9% NaCl (2.0 – 3.0 mL)
Manufacturer Afira Biosystems
Reconstituted stability Up to 28 days at 2°C – 8°C

Storage Requirements & Cold Chain Management

Store refrigerated at 2°C to 8°C (36°F to 46°F). Protect from direct light. Do not freeze. For pre-filled pens: once in use, the pen may be kept at room temperature (below 30°C / 86°F) for up to 21-28 days. For reconstituted vials: maintain in refrigerator at 2°C to 8°C and use sterile single-use syringes.

FAQ

Why should the vial never be vigorously shaken?

Peptides feature sensitive structural conformations. Vigorous shaking causes foaming and protein aggregation, significantly impairing biological potency.