Tirzepatide 60 mg lyophilized powder for solution for injection
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❄️ Temperature-controlled delivery (2–8°C) across the EU.
AFIRA Tirzepatide 60 mg Lyophilized provides pharmaceutical-grade tirzepatide in a vacuum-sealed sterile glass vial. The lyophilized formulation preserves peptide structural integrity and maximizes shelf life. Requires reconstitution with sterile 0.9% sodium chloride or bacteriostatic water prior to subcutaneous administration.
Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. By simultaneously activating both incretin pathways, it exerts synergistic metabolic control: promoting glucose-dependent insulin secretion from pancreatic beta cells, suppressing inappropriate glucagon release, slowing gastric motility, and stimulating central hypothalamic satiety circuits to curb appetite and enhance peripheral insulin sensitivity.
Reconstitution protocol: Slowly inject the diluent down the inner glass wall. Gently swirl the vial until the cake fully dissolves into a clear liquid. DO NOT SHAKE. Store the reconstituted solution in the refrigerator at 2°C to 8°C.
To ensure gastrointestinal tolerability, Tirzepatide administration must follow a stepwise escalation protocol. Treatment initiates at a low starting dose of 2.5 mg subcutaneously once weekly for the initial 4 weeks (adaptation phase). The dose is then increased to 5.0 mg once weekly. Subsequent increments of 2.5 mg may occur at minimum 4-week intervals based on clinical assessment and tolerance, up to the maximum dose of 15.0 mg weekly.
| Peptide purity (HPLC) | > 99.2% |
|---|---|
| Vial content | 60 mg Tirzepatide (Lyophilized Cake) |
| Dosage form | Sterile lyophilized powder for solution |
| Recommended diluent | Bacteriostatic Water or 0.9% NaCl (2.0 – 3.0 mL) |
| Manufacturer | Afira Biosystems |
| Reconstituted stability | Up to 28 days at 2°C – 8°C |
Store refrigerated at 2°C to 8°C (36°F to 46°F). Protect from direct light. Do not freeze. For pre-filled pens: once in use, the pen may be kept at room temperature (below 30°C / 86°F) for up to 21-28 days. For reconstituted vials: maintain in refrigerator at 2°C to 8°C and use sterile single-use syringes.
Peptides feature sensitive structural conformations. Vigorous shaking causes foaming and protein aggregation, significantly impairing biological potency.